Lipopolysaccharides (LPS) released from dying gram-negative bacteria (such as e.Coli) can trigger the body to release low levels of histamine. This should last about as long as die-off does, which varies from person to person, but generally 3-7 days. Just keep in mind that killing unwanted bacteria and making room for beneficial bacteria is a good thing. Since Phage Complete kills gram-negative bacteria this can temporarily cause histamine symptoms.
“The effect of bacterial lipopolysaccharide (LPS) on histamine release from human basophils. I. Enhancement of immunologic release by LPS… lipopolysaccharide (LPS)… enhanced by an average of sixfold the response of peripheral blood basophils obtained from allergic donors to several allergens in vitro as judged by release of histamine.” — https://www.ncbi.nlm.nih.gov/pubmed/2578909
“The potentiating effect of LPS was observed in grass pollen and dog dander allergic patients as well as in patients sensitized to E. coli or Staph, aureus bacteria… Bacteria can release histamine by immunological or nonimmunological mechanisms, and only the immunological histamine release was found to be potentiated by LPS. It is speculated that endotoxins reinforce release of histamine caused by allergens in allergic patients or by bacteria in persons sensitized to these microorganisms.” — http://onlinelibrary.wiley.com/doi/10.1111/j.1398-9995.1986.tb00288.x/abstract
So getting rid of this LPS producing bacteria is important as it produces (sheds) LPS molecules 24/7; again, killing unwanted bacteria and making room for beneficial bacteria is a good thing. LPS producing bacteria might actually be one of the reasons some people suffer from histamine symptoms even when not consuming any histamine containing / liberating foods.
Taking an antihistamine, such as Zyrtec, can help with symptom relief. There is also some evidence that it works as a mast cell stabilizer, to block the histamine (your body would release) from being release in the first place. Worth a try.
Following the FAQ advice for die-off and cutting back might help.
https://www.theguthealthprotocol.com/wp/phage-complete-faq/?Display_FAQ=1128
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